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Cheryl Guttman Krader
Balanced tip design minimizes need for longitudinal energy
Though there is a short learning curve for performing a direct phaco chop technique with a 45° balanced tip, it makes surgery more efficient by eliminating or minimizing the need for longitudinal energy.
Surgical gene therapy study for wet AMD yields mixed results
In a phase IIa study of patients with neovascular age-related macular degeneration, a single subretinal injection of rAAV.sFlt-1 gene therapy demonstrated acceptable safety, but not a complete or durable anti-VEGF response. Additional preclinical research is under way.
Investigational pipeline for DME looks promising
Pharmacotherapy research for diabetic macular edema is looking at targets other than VEGF inhibition to develop treatments that can be used as standalone intervention or may be complementary to current options.
New phase of OHTS about to begin for glaucoma care
The Ocular Hypertension Treatment Study (OHTS) provided evidence supporting early treatment of selected patients with OHT, especially in high-risk individuals identified by a glaucoma risk prediction model. A new phase designed to gather data to guide even more personalized care is about to begin.
CA-CXL expands candidates to eyes with thin corneas
Contact lens-assisted corneal crosslinking (CA-CXL) is a novel technique in which a riboflavin-soaked ultraviolet (UV) barrier-free soft contact lens is applied over the denuded cornea prior to UVA irradiation.
Intraocular medications gaining traction in cataract procedures
Although no new drug therapies entered cataract surgeons’ armamentarium in 2015, interest continues to grow in approaches for intraocular administration.
Study provides insight on long-term outcomes after hyperopic LASIK
Hyperopic LASIK (H-LASIK) has limited predictability and declining efficacy during long-term follow-up, but its safety remains good and patient satisfaction stays high, said Reena Mahendra Dave, MD.
Femtosecond laser-enabled approach allows treatment of high astigmatism
Femtosecond laser intrastromal arcuate keratotomy (AK) under a corneal flap is feasible and appears to be safe and effective for reducing high astigmatism, according to the early experience of António Limão, MD.
Presbyopia treatment aims to rejuvenate ‘lazy’ ciliary muscles
Microelectrostimulation of the ciliary body is a promising non-invasive technique for restoring accommodative loss in eyes with early presbyopia, said Luca Gualdi, MD.
Positive results reported for anti-interleukin-6 agent for uveitis
Intravenous administration of the anti-interleukin-6 (IL-6) agent tocilizumab (Actemra, Genentech) is well-tolerated in patients with non-infectious uveitis involving the posterior segment and showing promising efficacy, according to interim outcomes reported by Quan Dong Nguyen, MD.


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