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Cheryl Guttman Krader
Predictable rise in testosterone levels seen with implanted pellets
Serum testosterone concentration rises in a predictable manner after implantation of extended-release testosterone pellets (Testopel), and the dose response is not impacted by the patient's body mass index.
Antiandrogen shows durable antitumor activity in prostate cancer
Accumulating data from patients with progressive, castration-resistant prostate cancer enrolled in a phase I-II study of MDV3100 show this novel antiandrogen has durable antitumor activity in both pre- and post-chemotherapy populations.
Tissue digestion in lab finds sperm post-microdissection testicular sperm extraction
Analyses of data from a large series of men undergoing microdissection testicular sperm extraction (mTESE) showed that among patients who had no sperm found in the OR, 7% had sperm identified following tissue digestion and extensive searching in the laboratory.
Novel overactive bladder agent found efficacious, well tolerated
The investigational selective beta3-adrenoceptor agonist mirabegron effectively improves symptoms of overactive bladder and is very safe and well tolerated.
Phase III data support efficacy of denosumab in preventing skeletal events in men with metastatic prostate cancer
New analyses of data from the phase III study establishing the superiority of denosumab (XGEVA) to zoledronic acid (Zometa) for preventing skeletal-related events in men with bone metastases from castrate-resistant prostate cancer provide further evidence of the therapeutic value of the novel bone-targeted agent.
Radical prostatectomy offers no significant mortality reduction, according to study
After a median follow-up of 10 years, the intent-to-treat with radical prostatectomy did not significantly reduce all-cause or prostate cancer-specific mortality compared with active surveillance.
Robotic radical prostatectomy shows less morbidity than open technique
Early results from a prospective, randomized trial of men with clinically localized prostate cancer demonstrate robot-assisted laparoscopic prostatectomy is a safe technique associated with less morbidity than open retropubic radical prostatectomy.
Radical prostatectomy viable for locally advanced prostate cancer, according to study
Analyses of oncologic outcomes from men enrolled in a large, prospective, multicenter database support consideration of radical prostatectomy in the management of locally advanced prostate cancer.
Reweighed Charlson comorbidity index more accurate in men with prostate cancer
A reweighed Charlson comorbidity index (CCI) based on prostate cancer-specific data and long-term follow-up predicts long-term, other-cause mortality in prostate cancer patients better than the original CCI.
Dual-agent protocol may cut post-prostate biopsy infection rate
Results of a retrospective study documenting a significant risk of fluoroquinolone-resistant Escherichia coli infections after transrectal ultrasound-guided prostate biopsy (TRUSP) prompted a change in the antibiotic prophylaxis protocol for men undergoing this diagnostic procedure at one large institution.


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