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    Ranibizumab proves instrumental for DME patients in RIDE, RISE trials

    Provided improved visual acuity, diabetic retinopathy remained stable over the long-term

    Take-home message: Ranibizumab provided improvements in visual acuity and DR that were stable over the long term when the drug was administered on an as-needed regimen to patients with diabetic macular edema in the RIDE and RISE trials.

     

    Baltimore—Ranibizumab (Lucentis, Genentech) provided improvements in visual acuity and diabetic retinopathy (DR) that were stable over the long term when the drug was administered on an as-needed regimen to patients with diabetic macular edema (DME) in the RIDE and RISE trials, said Michael J. Elman, MD.

    Obesity and diabetes have been clearly documented to be growing problems in the United States, according to the Centers for Disease Control and Prevention (CDC) that has tracked the steady and concomitant rise of the two diseases. With obesity defined as a body mass index of 30 kg/m2 and higher, the CDC data showed that the incidence of obesity rose from under 14% in some areas of the country and 14.0% to 17.9% in others in 1994 to 26% and higher by 2010.

    With this, the incidence of diabetes during the same time frame almost doubled from less than 4.5% and from 4.5% to 5.9% in some areas in 1994 to 9.0% and over in a substantial portion of the United States, said Dr. Elman, who is in private practice in Baltimore.

    Along with those increases come visual loss from DR and its complications including DME, hemorrhage from new vessels, retinal detachment, and neovascular glaucoma. Over the decades the standard treatment for DR, panretinal photocoagulation (PRP), decreased the risk of blindness but was associated with its own serious set of complications.

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