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    Ranibizumab provides solid safety, efficacy in real-world population

    Data at 1 and 2 years follow-up indicated expected relative preservation of visual acuity

     

    “This is encouraging and suggests a strong treatment effect,” he said. “Similar findings were observed in patients with DME and branch and central vein occlusions.”

    Results

    In patients with AMD, at 12 months there was a change in the visual acuity score of +4.4 letters in the treatment-naïve group and a loss of 1.5 letters in those previously treated with ranibizumab over the 12 months (mean injections, 4.7 and 4.3, respectively).

    “Interestingly, when evaluating patients followed for less than 1 year, 1 to 2 years, 2 to 3 years, 3 to 4 years, 4 to 5 years, or 6 years, almost the same pattern is seen,” Dr. Mitchell said. “Over the 12 months, there was a loss of about 1.5 letters over that period regardless of how long patients had been receiving treatment.”

    When patients were stratified by baseline visual acuity, in patients with a visual acuity of 20/80 or lower, a mean improvement was seen over the 12 months.

    However, for those with a visual acuity of 20/60, it was the same and for those with 20/40 or better, a small decrease in visual acuity was seen over the follow-up period, he said.

    The number of injections among the visual acuity groups did not differ, he noted.

    When patients were stratified by age, patients under 65 years had steep improvements in visual acuity. However, even patients over 85 years achieved improvements in visual acuity but had started with somewhat worse visual acuity.

    “The visual acuity gain in older patients was not as great compared with the younger ones,” he said.

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