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    Integrin peptide yields positive outcomes for VMA, VMT in phase II trial

    Dual mechanisms of action appear to inhibit new blood vessel formation, reduce leakage

    Take-home message: A new possible therapy for vitreomacular adhesion and vitreomacular traction had positive results in a phase II trial.

     

    Orlando—A phase II clinical trial with the drug, ALG-1001 (Luminate, Allegro Ophthalmics), for vitreomacular traction (VMT) or vitreomacular adhesion (VMA) met its primary endpoint, according to study data.

    The trial evaluated the safety and efficacy of ALG-1001 intravitreal injections in 106 study subjects. The trial was prospective, double-masked, and placebo-controlled.

    The study divided 106 study subjects into three ALG-1001 groups (2.0 mg, 2.5 mg, and 3.2 mg) and a balanced salt solution placebo group. Sixty-five percent of eyes treated with the 3.2 mg dose of ALG-1001 had release of VMT or VMA by day 90, which was the end of the study, compared with 9.7% in the placebo control group.

    No drug toxicity or intraocular inflammation occurred.

    “These safety results are consistent with previously conducted [ALG-1001] studies on human subjects where there were no rod or cone photoreceptor dysfunction on full-field electroretinogram testing, no afferent pupillary defects, and no evidence of retinal tears or detachments,” according to a prepared statement.

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