ARVO 2007 - Ophthalmology Times

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ARVO 2007

Bioptic telescope aids drivers with AMD

May 8, 2007

Drivers with age-related macular degeneration (AMD) who used a small, spectacle-mounted bioptic telescope reported fewer self-imposed driving restrictions when compared with drivers with AMD who did not use the telescope. Alex R. Bowers, PhD, MCOptom, of the Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, noted that drivers with AMD who used the telescope drove greater distances and to more paces and reported fewer difficulties in potentially challenging situations, such as night driving, heavy traffic, or rain.

Optical coherence tomography: cellular and functional retinal imaging

May 8, 2007

Wolfgang Drexler, PhD, was instrumental in the development of optical coherence tomography (OCT) and has contributed significantly to advances such as ultra high-resolution OCT. But befitting someone who is recognized for his future promise as well as his prior accomplishments, Dr. Drexler has no shortage of ideas for enhancing OT's value as a clinical and research tool. Dr. Drexler, professor of biomedical engineering at Cardiff University, Wales, received the Cogan Award Tuesday night.

Bevacizumab tested in treatment of severe ROP

May 8, 2007

In a small case series, all eyes in infants treated with bevacizumab (Avastin, Genentech) for retinopathy of prematurity (ROP) showed a decrease in fluorescein leakage from neovascularization after the injection. Although this series involved only five eyes in three patients with short-term follow-up, the results suggest that bevacizumab could be an alternative for treatment of severe ROP that is refractive to conventional laser treatment, said Shunji Kusaka, MD, Department of Ophthalmology, Osaka University Medical School, Suita, Japan.

ANCHOR study of time course of visual acuity changes: ranibizumab benefit stable over 2 years

May 8, 2007

Analysis of the time course of visual acuity outcomes during the first year of the ANCHOR study indicates that the mean visual acuity benefit of ranibizumab (Lucentis, Genentech) compared with photodynamic therapy (PDT) with verteporfin (Visudyne, Novartis) was observed after the first month of treatment, but that even patients who did not show this early benefit might respond later in the treatment course, said Jeffrey Heier, MD, Ophthalmic Consultants of Boston.

Efficacy and safety of corticosteroid implants for DME an active area of research

May 8, 2007

The central role of blood-retinal-barrier breakdown in the development of diabetic macular edema provides a rationale for exploring the use of corticosteroids as a treatment option, said Glen J. Jaffe, MD, professor of ophthalmology, Duke University Eye Center, Durham, NC.

Bevacizumab rescue therapy after pegaptanib: minimal visual acuity improvement

May 8, 2007

Primary bevacizumab (Avastin, Genentech) therapy for choroidal neovascularization (CNV) in age-related macular degeneration resulted in two to three ETDRS lines of improvement, which is similar to that with ranibizumab (Lucentis, Genentech). Bevacizumab rescue therapy administered following treatment with pegaptanib (Macugen, OSI/Eyetech, Pfizer Ophthalmics) resulted in minimal improvement, said William Freeman, MD, from the Department of Ophthalmology, Shiley Eye Center, University of California San Diego, La Jolla, CA.

MEPEDS: Older children more likely to develop strabismus, amblyopia

May 8, 2007

There is no difference in the prevalence of amblyopia and strabismus in a population of Hispanic and African-American children preschool children and the prevalence of the two pathologies increases with age, according to Rohit Varma, MD, MPH, from the University of Southern California, Keck School of Medicine, Los Angeles.

Evolution in understanding of DME suggests new targets, treatment paradigms

May 8, 2007

While there are extensive data supporting the concept that antiVEGF agents may have a role in the treatment of diabetic macular edema (DME), emerging knowledge about DME pathogenesis is suggesting alternate therapeutic targets and new paradigms for multidrug treatment, said Lloyd P. Aiello, MD, PhD, director, Beetham Eye Institute, Joslin Diabetes Center, Boston.

Latex bead injection model useful for studying retinal ganglion cell loss

May 8, 2007

A new model for latex bead injections demonstrates that this is a viable approach to increasing IOP and inducing loss of retinal ganglion cells in rats, said Rebecca M. Sappington, PhD, research fellow, Vanderbilt University, Vanderbilt Eye Institute, Nashville.

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