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    Digital imaging screening may identify infants with referral-warranted ROP

    Telemedicine system could decrease number of unnecessary exams, identify children who need treatment


    When investigators compared the diagnostic examination with the grading evaluation for one imaging session for an infant, they found a sensitivity of 90% and a negative predictive value of about 97%. When they looked at all the imaging sessions for an infant, they found a sensitivity of 97%, Dr. Quinn noted.

    Finally, when investigators looked at the last session before ROP treatment in 162 infants, the sensitivity exceeded 98% with a negative predictive value of 99%.

    “There is strong support for the validity of a telemedicine system to detect eyes of at-risk infants who require a diagnostic evaluation by an ophthalmologist experienced with ROP,” he said.

    • Factors still being analyzed include:
    • The circumstances under which telemedicine screening in ROP can be cost-effective in the United States;
    • The ability to return grading to the neonatal intensive care unit within 24 hours;
    • The ability to detect referral-warranted ROP using computerized image analysis;
    • The real need for five retinal images to determine the presence of referral-warranted ROP;
    •  The possibility of incorporating early growth parameters into the prediction models to tailor imaging session, and
    • The possibility of improving the grading protocol, Dr. Quinn concluded.


    Graham E. Quinn, MD, MSCE

    E: [email protected]

    Dr. Quinn receives support from the National Eye Institute/National Institutes of Health.



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