The top glaucoma papers, as determined by the Ophthalmology Times
Editorial Advisory Board, will cover a broad spectrum of topics at the 2003
Annual Meeting of The Association for Research in Vision and Ophthalmology
(ARVO), from imaging to surgery and wound healing.
A mini-symposium, entitled "Progressive Structural and Functional
Injury in Glaucoma," will be the highlight of the glaucoma presentations.
This session, scheduled for Tuesday, will provide a nice overview and a
framework for judging the relevance of the other sessions, where new data
are presented.
The papers (Program #2043-#2049) for the mini-symposium include:
"Biology of Progressive Optic Nerve Injury in Glaucoma" by
George Cioffi, MD;
"Progressive Central Nervous System Injury in Glaucoma" by
Neeru Gupta, MD;
"Risk Factors that Predict Glaucoma Progression" by David
Friedman, MD;
"Detection of Progressive Structural Injury in Glaucoma"
by David Greenfield, MD;
"Detection of Progressive Functional Injury in Glaucoma"
by E.Z. Blumenthal, MD;
"New Approaches in Detecting Progression" by P.A. Samples;
"Does Structural Injury Predict Future Functional Injury?"
by Christopher Girkin, MD
Another glaucoma session expected to draw physicians' interest is "Surgery
and Wound Healing III," which is scheduled for Thursday. The session
addresses some new approaches and thought about glaucoma, but also touches
base on some time-tested topics, such as on effectiveness and safety of
viscocanalostomy and trabeculectomy. The papers (Program #4290-#4296) in
this session are:
"Gene Therapy to Modulate Wound Healing Following Trabeculectomy:
Transfection of Tenon Fibroblasts with Oligonucleotides" by Holger
Mietz, MD, et al.;
"Long-Term Modulation of Ocular Scarring by Matrix Metalloproteinase
Inhibition-Comparison with Mitomycin-C Treatment Following Experimental
Glaucoma Filtration" by T.T. L. Wong, et al.;
"Maintenance of Long-Term Bleb Function by Prolonged Treatment
with CAT-152, an Anti-Transforming Growth Factor-ß2 (TGF-ß2)
Antibody: Enhanced Effects over 5-Fluorouracil (5-FU)" by A.L. Mead,
et al.;
"Yag Laser Iridotomy in Pigment Dispersion Syndrome: 10 Years
Later" by N. Ungaro, et al.;
"A Prospective, Randomized, Comparative Study between Endoscopic
Cyclophotocoagulation and the Ahmed Drainage Implant in Refractive Glaucoma"
by Francisco Lima, MD, et al.;
"Viscocanalostomy versus TrabeculectomyThree Years After"
by Roberto Garassa, MD, et al.;
"Fornix versus Limbus-Based Conjunctival Flap Trabeculectomy and
the Incidence of Bleb-Related Infection" by P.A. Rai, et al.
Two other sessions that should attract some attention from ophthalmologists
in dealing with glaucoma issues are "Neuroprotection, Normal Tension
Glaucoma, and Ocular Blood Flow II" and "Glaucoma Epidemiology
I," scheduled for Tuesday and Wednesday respectively.
Some of the better papers to be presented in the neuroprotection, normal
tension glaucoma, and ocular blood flow session include:
"Optineurin Mutations in Patients with Low Pressure Glaucoma (LPG):
No Evidence for E50K Founder Effect" by M. Sarfarazi, et al. (Program
#2148);
"TNF-a-Mediated Death of Retinal Ganglion Cells Following Optic
Nerve Crush Injury in Mice" by G. Tezel, et al. (Program #2149);
"Imaging Apoptosis in the Living Eye: A Novel Method of Assessing
Retinal Ganglion Cells and Glaucoma" by M.F. Cordeiro, et al. (Program
#2150);
"A New Route for Therapeutic Intervention: Topical Vaccination
for Acute and Chronic Glaucoma" by S. Bakalash, et al. (Program #2151).
In the glaucoma epidemiology session, here are the some of the top papers
to be presented:
"Topical Treatment of Persons with Ocular Hypertension: Who Should
Be Treated? An Economic Evaluation from the Ocular Hypertension Treatment
Study (OHTS)" by S.M. Kymes, et al. (Program #3168);
"Relationship Between Thyroid Disease and Glaucoma: The Blue Mountain
Eye Study" by A.J. Lee, et al. (Program #3169);
"Risk Indicators of Glaucoma in Families" by B.E.K. Klein,
et al. (Program #3171);
"The Prevalence of Glaucoma in Population-Based Sample of Elderly
Saudis" by Scott Smith, MD, et al. (Program #3172);
"Prevalence of Open-Angle Glaucoma and Ocular Hypertension in
Latinos. The Los Angeles Latino Eye Study (LALES)" by Rohit Varma,
MD, et al. (Program #3173).
A good number of other glaucoma sessions are planned throughout this
year's ARVO meeting. Among the paper presentations that ophthalmologists
should consider looking at are:
"Optic Nerved Head Topography Shows Diurnal Variation in Untreated
Primary Open Angle Glaucoma" by M. Sehi, et al. (Program #979);
"Correlation of Visual Field Sensitivity and Retinal Nerve Fiber
Layer Thickness as Measured by Scanning Laser Polarimetry by D.F. Garway-Heath,
et al. (Program #980);
"Corneal Thickness as a Risk Factor for Visual Field Loss in Patients
with Glaucomatous Optic Neuropathy" by F.A. Medeiros, et al. (Program
#1043);
"Central Corneal Thickness as a Risk Factor for Advanced Glaucoma
Damage" by J.S. Weizer, et al. (Program #1045);
"Continuum Finite Element Modeling of the Normal and Early Glaucomatous
Monkey Optic Nerve Head" by A.J. Bellezza, et al. (Program #1094);
·"Diagnosis of Glaucoma by Analysis of Auto-Antibody Repertoires"
by Fran Grus, MD, et al. (Program #2100);
"Miniature Continuous Intraocular Pressure Sensor" by Leon
Partamian, MD, et al. (Program #2105);
"Robotic Biological Microfistula Implantation for Glaucoma Drainage
Surgery (A Preliminary Report)" by D.-Y. Yu, et al. (Program #2106);
"Ocular Localization of Optineurin Protein in Human, Monkey, and
Mouse Eyes" by T. Rezaie, et al. (Program #3226);
"Optineurin Sequence Variants Do Not Predispose to Primary Open
Angle Glaucoma" by J.W. Walter, et al. (Program #3227);
"Accelerated Optic Disc and Visual Field Damage in POAG Patients
Associated with the Myocilin Mt.1(+) Promoter Variant" by J.R. Polansky,
et al. (Program #3230);
"Iris Darkening after Short-Term Exposure to Latanoprost Is Due
to a Small Increase in Melanin Granule Size" by I. Grierson, et al.
(Program #4231);
"Impact of Prostaglandin F2-alpha Agonists on the Central Corneal
Thickness" by A. Viestenz, et al. (Program #4232);
"Effect of Corneal Thickness, Curvature, and Axial Length on Goldmann
Applanation Tonometry" by L.E. Pillunat, et al. (Program #4237).
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