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    Biomarker research centers on early glaucoma diagnosis

    By Fred Gebhart

    The search for glaucoma biomarkers is kicking into high gear. A multiyear grant, funded by Catalyst for a Cure, has already produced new biomarker candidates and novel techniques that promise to advance research in glaucoma, as well as in retinitis pigmentosa, gene therapy of inherited photoreceptor conditions, and other conditions.

    “The way this program is structured pushes us to be very creative,” said Alfredo Dubra, PhD, assistant professor and co-director of the Advanced Ocular Imaging Program at the Medical College of Wisconsin, Milwaukee. “Three of the four of us were not even working in glaucoma before this project. We are encouraged to bring in out-of-the-field ideas. And it is paying off.”

    The GRF research program, entitled “Biomarker Initiative Program,” has four principal investigators. Dr. Dubra presented current results during “GRF Update: Adaptive Optics and Glaucoma Biomarkers.” The co-investigators are: Jeffrey Goldberg, MD, PhD, professor of ophthalmology and director of research at the Shiley Eye Center, University of California, San Diego (UCSD); Andrew Huberman, PhD, assistant professor of neurosciences/neurobiology/ophthalmology at Shiley Eye Center and UCSD; and Vivek J. Srinivasan, PhD, assistant professor of biomedical engineering at the University of California, Davis.


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