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    Sustained drug delivery moving toward clinical use


    Kala Pharmaceuticals

    Kala makes nanoparticles designed to penetrate the mucus barrier protecting the eye and other tissues. The mucus-penetrating platform (MPP) uses nanoparticles smaller than the pores in the mucin mesh that protects the eye.

    “Our drug particles have been coated with an engineered polymer layer to penetrate the mucin layer, like they were coated with Teflon, to reach the target tissue,” said Chief Medical Officer Kim Brazzell, PhD.

    When applied to the surface of the eye, particles quickly migrate to the cornea, aqueous humor, retina, choroid, and sclera but not into the aqueous humor. That migration, via the suprachoroidal space, could transform glaucoma treatment with the potential for neuroprotection with a sustained release topical agent.

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