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    Dry eye therapy seeks to fill unmet need in artificial tears

    A look at the history of artificial tears traces progression of products, dry eye market



    Through the generations of artificial tears, ophthalmology has seen a number of advanced therapeutic options.


    Andover, MA—Dry eye—one of the most common ophthalmic diseases affecting 1 in 3 patients who seek treatment from an ophthalmologist—can drastically impact the quality of life of those plagued by the disease.1

    Unfortunately, dry eye is also one of the most difficult diseases to study and consequently, the number of truly effective therapies is limited. What sounds simple in therapy is not so simple in practice, and that is creating an artificial tear to target the signs and symptoms of dry eye while restoring the ocular surface.

    The progression of artificial tears

    The artificial tear market has changed drastically over the years, and ophthalmology is now into the fourth generation of artificial tears.

    First generation: The first generation of tear substitutes is saline-based artificial tears, composed of isotonic sodium chloride. Generally speaking, these artificial tears spread poorly across the ocular surface and their short retention time leads to transient symptoms relief and very high frequency of instillations. While these products can provide hydration without blurring, they do not protect against evaporation or allow for optimal spreading on the ocular surface.

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