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    Dry eye therapy seeks to fill unmet need in artificial tears

    A look at the history of artificial tears traces progression of products, dry eye market

     

    Fourth generation: The unmet need for an all-encompassing artificial tear was met with the development of the fourth-generation lipid emulsions. Lipid emulsions reduce tear evaporation without impairing vision while also providing hydration and osmocorrection. These nanoemulsions were developed to improve ocular bioavailbilty of lipophilic or poorly water-soluble drugs and are quite effective ocular drug delivery vehicles. To date, all emulsions marketed with the exception of one are anionic, including Systane Balance (Alcon) and Optive Plus (Allergan), and due to electrostatic repulsion, have a poor retention time on the ocular surface. Cationic oil-in-water emulsions extend the benefits of negatively charged oil-in-water emulsions. Retaine MGD (OCuSOFT) is the only preservative-free, cationic emulsion currently available. Its composition is designed to target all three layers of the tear film and improves spreading and residence time on the ocular surface, enhancing the protection and restoration of a healthy tear film and corneal epithelium.

    Need for complete OTC artificial tear

    Through the generations of artificial tears, there have been a number of advanced therapeutic options, but none that come fully equipped to tackle dry eye. In eye drop formulations of any kind, one of the most significant challenges is that the product is rapidly eliminated from the ocular surface following instillation due to a variety of ocular barriers.2 An artificial tear with an improvised residence time can combat the barriers to drug delivery and provide a more complete system for dry eye symptom relief.

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