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    Dry eye therapy seeks to fill unmet need in artificial tears

    A look at the history of artificial tears traces progression of products, dry eye market


    Retaine MGD is a unique preservative-free artificial tear option that serves to address the unmet needs of the artificial tear industry. The drug contains a proprietary cationic oil-in-water nanoemulsion technology with novel bioadhesive properties (Novasorb). The principle of the technology is based on electrostatic interactions between the positively charged oil nanodroplets and the negatively charged ocular surface. This electrostatic attraction increases the residence time on the ocular surface and enhances the ocular drug bioavailability.3-5 By acting against the vicious cyclical nature of dry eye to relieve symptoms and restore the ocular surface, fourth-generation products, like Retaine MGD, exemplify the optimal tear substitute for dry eye disease.



    1. Gayton JL. Etiology, prevalence, and treatment of dry eye disease. Clinical Ophthalmology. Auckland, N.Z. 2009;3:405-412.

    2.  Lallemand F, Daull P, Benita S, Buggage R, Garrigue JS. Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb. J Drug Delivery. 2012;2012:604204.

    3. Daull P, Lallemand F, Garrigue JS. Benefits of cetalkonium chloride cationic oil-in-water nanoemulsions for topical ophthalmic drug delivery. Journal of Pharmacy and Pharmacology. May 26, 2013.

    4. Rabinovich-Guilatt L, Couvreur P, Lambert G, Dubernet C. Cationic vectors in ocular drug delivery. J Drug Target. 2004;12:623-633.

    5. Royle L, Matthews E, Corfield A, et al. Glycan structures of ocular surface mucins in man, rabbit and dog display species differences. Glycoconjugate Journal. 2008;25:763-773.

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