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    Hydrogel punctal plugs safe, viable means for sustained drug delivery

    Fluorescein aids visualization, allowing physicians and patients to monitor presence

     

    Take-Home

    Hydrogel punctal plugs may be a safe and viable method for delivery of anti-glaucoma drugs in the future.

     

    Dr. Noecker

    Norwalk, CTHydrogel punctal plugs (Ocular Therapeutix) loaded with fluorescein for visualization were evaluated in subjects for 1 year. The devices were found to be easy or very easy to insert, indicating that the plugs may be a safe and viable method of drug delivery of anti-glaucoma drugs in the future.

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    The hydrogel platform is comprised of drug-eluting punctal plugs. The tailored drug release is compatible with a wide range of pharmaceuticals, such as travoprost, dexamethasone, and moxifloxacin, among others. The device is placed noninvasively in the intracanalicular space through the punctum.

    “The comfort and retention of the device have been demonstrated for up to 3 months,” said Robert J. Noecker, MD, in private practice, Norwalk, CT.

     

    NEXT:Presence of the plugs

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