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    Autoimmune retinopathy: While uncommon, viable option for unexplained vision loss

    Careful history, ERG, anti-retinal antibody testing can pinpoint diagnosis


    If performing anti-retinal antibody testing, Dr. Lam advised using a CLIA lab and testing for specific antibodies, such as recoverine, enolase, CRMP-5, arrestin, aldolase, glyceraldehyde-3-phosphate, dehydrogenase, and carbonic anhydrase II. The 23-kDA protein antibody must be verified using a purified recoverin on Western blot to verify presence of anti-recoverin antibodies, he added.

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    A diagnosis of autoimmune retinopathy is supported if there is one of the specific antibodies noted above that are associated with paraneoplastic retinopathy.

    “Nonspecific anti-retinal antibodies may imply autoimmune retinopathy–or may be the physiologic results of retinal degeneration from other causes,” Dr. Lam  said.


    Byron L. Lam, MD

    E: [email protected]

    This article was adapted from Dr. Lam’s presentation during the 2014 meeting of the American Academy of Ophthalmology. Dr. Lam did not indicate any proprietary interests related to the topic.

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