/ /

  • linkedin
  • Increase Font
  • Sharebar

    Cellular therapy of the corneal stroma: Real approach or science fiction?

    Extraocular mesenchymal stem cells could be an alternative to classical corneal transplantation




    1.     De Miguel MP, Casaroli-Marano RP, Nieto-Nicolau N, et al. Frontiers in Regenerative Medicine for Cornea and Ocular Surface. In: Rahman A, Anjum S. Frontiers in Stem Cell and Regenerative Medicine Research. 1st ed. PA: Bentham e-Books, Vol. 1, 2015;92-138.

    2.     Arnalich-Montiel F, Pastor S, Blazquez-Martinez A, et al. Adipose-derived stem cells are a source for cell therapy of the corneal stroma. Stem Cells. 2008;26:570–579.

    3.     Alió del Barrio JL, Chiesa M, Gallego Ferrer G, et al. Biointegration of corneal macroporous membranes based on poly(ethyl acrylate) copolymers in an experimental animal model. J Biomed Mater Res A. 2015;103:1106–1118.

    4.     Alió del Barrio JL, Chiesa M, Garagorri N, et al. Acellular human corneal matrix sheets seeded with human adipose-derived mesenchymal stem cells integrate functionally in an experimental animal model. Exp Eye Res. 2015;132:91–100.

    5.     Espandar L, Bunnell B, Wang GY, et al. Adipose-derived stem cells on hyaluronic acid-derived scaffold: a new horizon in bioengineered cornea. Arch Ophthalmol. 2012;130:202–208.

    6.     Mittal SK, Omoto M, Amouzegar A, et al. Restoration of Corneal Transparency by Mesenchymal Stem Cells. Stem Cell Reports. 2016;7:583-590.

    7.     Demirayak B, Yüksel N, Çelik OS, et al. Effect of bone marrow and adipose tissue-derived mesenchymal stem cells on the natural course of corneal scarring after penetrating injury. Exp Eye Res. 2016;151:227-235.

    8.     Du Y, Carlson EC, Funderburgh ML, et al. Stem cell therapy restores transparency to defective murine corneas. Stem Cells. 2009;27:1635–1642.

    9.     Liu H, Zhang J, Liu CY, et al. Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice. PLoS One. 2010;5:e10707.

    10.  Coulson-Thomas VJ, Caterson B, Kao WW. Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of mucopolysaccharidosis VII mice. Stem Cells. 2013;31:2116–2126.

    11.  Kao WW, Coulson-Thomas VJ. Cell Therapy of Corneal Diseases. Cornea. 2016;35 Suppl 1:S9-S19.

    12.  De Miguel MP, Fuentes-Julián S, Blázquez-Martínez A, et al. Immunosuppressive properties of mesenchymal stem cells: advances and applications. Curr Mol Med. 2012;12:574-591.

    13.  Alió del Barrio JL, El Zarif M, de Miguel MP, et al. Cellular Therapy with Human Autologous Adipose-derived Adult Stem Cells for Advanced Keratoconus. Cornea. 2017;36:952-960.

    14.  Alió JL, Piñero DP, Alesón A, et al. Keratoconus-integrated characterization considering anterior corneal aberrations, internal astigmatism, and corneal biomechanics. J Cataract Refract Surg. 2011;37:552-568.


    Dr Jorge L. Alió del Barrio, MD, PhD

    E: [email protected]

    Dr Alió del Barrio is a surgeon at the Cornea, Cataract and Refractive Surgery Unit, Vissum Corporación, Alicante, Spain and professor “ad Honorem” at the Miguel Hernández University’s School of Medicine, Alicante, Spain. He has no financial interests to disclose.


    Professor Jorge L. Alió MD, PhD, FEBOphth

    E: [email protected]

    Prof. Jorge L. Alió is professor and chairman of ophthalmology at the University Miguel Hernández de Elche, Alicante, Spain. He is also founder of Vissum Corporation, Spain, and of the Jorge Alió Foundation for the Prevention of Blindness. He has no financial interests in the subject matter.


    Dr Mona El Zarif, OD

    E:[email protected]

    Dr El Zarif is the owner of Optica General S.A.R.L. Saida in Lebanon and head of the Optometry and Contactology department. She has no financial disclosures to make.




    New Call-to-action


    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available


    View Results