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    Dropless cataract surgery effective choice without compliance issues

    Study finds therapy seems to be more practical, efficacious as standard of care

    Dropless prophylaxis in patients scheduled for cataract surgery seems to be more practical than and as efficacious as the standard of care for use in this patient population.

    Evaluation of an intravitreal injection containing antibiotic and anti-inflammatory drugs during cataract surgery showed no differences between the patients randomly assigned to the intravitreal injection group and the standard care group.

    Patients expressed high satisfaction with the dropless procedure.

    One of the key factors in cataract surgery is the use of prophylactic topical antibiotics and anti-inflammatories administered to prevent postoperative infections, such as endophthalmitis and inflammation.

    While the need for instillation of these drugs is paramount, poor patient compliance with the postoperative regimen is a big concern.

    According to Helga P. Sandoval, MD, MSCR, a number of factors can come into play here: the patient’s inability to self-administer the drops, a lack of understanding of the importance of using the prophylactic treatment, a lack of understanding of the instructions regarding the method of drop administration and storage, forgetfulness, and dislike of the need to instill the drops multiple times a day for from 2 to 4 weeks postoperatively.

    Dr. Sandoval, director of research, Carolina Eyecare Physicians LLC and adjunct professor, Storm Eye Institute, Medical University of South Carolina, Charleston, and colleagues theorized that eliminating the postoperative drop regimen altogether and substituting an intravitreal injection of the required drugs intraoperatively would solve the compliance problems.

    The investigators designed a study in which they compared use of an injectable compound containing an antibiotic and anti-inflammatory drugs (triamcinolone acetonide, moxifloxacin, and vancomycin [TriMoxiVanc]) with or without a topical, nonsteroidal, anti-inflammatory drug during cataract surgery to the standard of care that involves instilling three topical medications into the eye over an extended period postoperatively.

    Study breakdown

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