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    Drug-delivery technologies will transform care


    Euclid Systems

    Euclid Systems is developing collagen-based vehicles. Viscous formulations are injected through a 30-gauge cannula or needle and form homogenous beads within one minute. Films and wafers can be designed to degrade from a few hours to 6 months and longer and implanted.

    Collagen is already used in FDA-approved or cleared ophthalmic devices, said Chief Scientific Officer Dale DeVore, PhD. It can be manipulated into different physical forms with controlled bioresporption characteristics. In vitro studies using gel formulation and rabbit studies in rabbits show steady state delivery of latanoprost for 180 days.

    “Our vehicle can be made in almost any physical configuration–gels, wafers, rods, fibers–to fit the target tissue and delivery method,” DeVore said. “It can be loaded with almost any drug and shows stead state distribution with both hydrophilic and hydrophobic agents.”


    Replenish is developing the world’s smallest, refillable, implantable pump. The pump is inserted into the vitreous, where it both measures IOP hourly and delivers daily drug doses of 200 nL to 10 uL. The physician reads IOP data remotely and changes drug dosing as appropriate.

    The pump is invisible from the outside and holds 6 months of drug. The reservoir is cleaned and refilled in the clinic using a proprietary 31-gauge needle system. A rabbit model shows a single infusion directly next to the ciliary body causes sustained IOP lowering.

    “We have the opportunity to combine continuous IOP-monitoring with therapeutic delivery of medication,” said Sean Caffey, MD, co-founder and chairman. “The physician can change the dose remotely as needed. It can even be set to intervene while the patient is sleeping. Marrying the therapeutic with the diagnostic is the solution for glaucoma.”

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