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    Drug-loaded plug eases adherence issues for patients, physicians

    Dexamethasone intracanalicular depot provides sustained, tapered delivery with strong safety profile

     

    Safety profile

    The good news, he added, is that both trials showed very strong safety results.

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    There were no product- or treatment-related serious adverse events in either study. There was one case of conjunctivitis in the placebo arm of the first study and one case of dacryocanaliculitis in the placebo arms of the second study. The first study had one patient with eyelid irritation and one with increased lacrimation, while the second study had one patient with an IOP increase of 10 mm Hg or more over baseline.

    Related: Cataract surgery may benefit certain PAC/PACG patients

    “We saw a very strong safety profile in both studies,” Dr. Gira said. “The surgeons all loved the system and so did the patients. Not having to worry about drug delivery, not having to worry about removing the plug, and not having any significant adverse events are huge advantages that you just don’t get with eye drops.”

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    Joseph Gira, MD

    E: [email protected]

    This article was adapted from Dr. Gira’s presentation at the 2016 meeting of the American Society of Cataract and Refractive Surgery. Dr. Gira has no financial relationship with Ocular Therapeutix. Sustained-release intracanalicular depots are investigational new drugs and not commercially available in the United States.

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