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    How 24-hour IOP measurements vary with glaucoma treatment


    Less is known about the relationship of laser trabeculoplasty to circadian characteristics of IOP. Still, a handful of studies have produced interesting results, among them:

    • In previously untreated POAG patients, circadian IOP fluctuation decreased from 7.9 mm Hg at baseline to 3.6 mm Hg 5 years after argon laser trabeculoplasty. In medically treated POAG patients, fluctuation decreased from 7.7 mm Hg to 5.8 mm Hg.

    Related: Better alternatives to standalone prostaglandin analog therapy

    • In glaucoma of an unspecified type, argon laser trabeculoplasty decreased fluctuation by 25%.

    • In open-angle glaucoma whose target IOP was not reached with medication, argon laser therapy meaningfully decreased nocturnal but not diurnal IOP. (This finding conflicted with other studies.)

    Related news: How MIGS procedure surpasses a trabeculectomy

    • Selective laser trabeculoplasty reduced fluctuation by 46% while latanoprost reduced fluctuation by 64% in patients with POAG or ocular hypertension.

    • The amplitude of 24-hour fluctuation was significantly reduced with selective laser trabeculoplasty in patients who had washed out of their topical medication therapy.

    IOP fluctuations following trabeculectomy

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