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    How 24-hour IOP measurements vary with glaucoma treatment

     

    A variety of studies have also examined 24-hour fluctuations in IOP following trabeculectomy. Some of the findings:

    • IOP ranged by 4.8 mm Hg between 8 a.m. and 6 p.m. in patients with open-angle glaucoma treated with trabeculectomy.

    • IOP ranged 10-17 mm Hg in patients who underwent a trabeculectomy with adjunctive 5-fluorouracil versus 14-22 mm Hg in patients who had a trabeculectomy without the antimetabolite.

    Learn more: Impressive IOP results from second-generation microinvasive surgery

    • In a group of patients with unspecified glaucoma, diurnal fluctuation of IOP was significantly greater among those treated with medicine than in those treated with trabeculectomy, even though the difference in mean IOP was not significantly different.

    • In patients with advanced open-angle glaucoma matched for daytime IOP at 10 a.m., those treated with trabeculectomy had a significantly lower mean IOP, peak IOP and fluctuation in IOP than those treated medically.

    • In patients with POAG who took a water-drinking test, mean diurnal IOP was lower with trabeculectomy or deep sclerectomy with collagen implant (DSCI) compared with latanoprost monotherapy, but the fluctuation was similar regardless of therapy.

    The authors concluded by describing a novel wireless telemetry sensor for monitoring IOP in POAG, consisting of a silicon contact lens with a micro-electromechanical system (Sensimed AG). They noted a recent study finding that the device did not correlate Goldmann IOP readings, and did not detect differences in IOP between sitting and supine positions.

    They called for new technology to make continuous monitoring feasible for everyone whose IOP is being treated.

    Recent glaucoma news: How a novel device reliably measures iridocorneal angles

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