/ /

  • linkedin
  • Increase Font
  • Sharebar

    Hypochlorous acid eyelid wash reduces bacterial load

    Application did not alter diversity of bacteria recovered but can reduce symptoms related to overgrowth

     

    Direct approach

    Hypochlorous acid is the bactericidal element used by macrophages and other components of the innate immune system to directly destroy invading microbes. Where traditional antibiotics use subtle mechanisms, such as interference with cell wall synthesis, DNA gyrase, topoisomerase 4 DNA replication or other pathways that can be circumvented, hypochlorous acid directly attacks and kills pathogens.

    Blog: 6 lessons to take away from the presidential race

    “No one product works for every patient, although this is almost universal for meibomian gland dysfunction, dry eye, and blepharitis,” Dr. Epstein said.

    “More importantly, hypochlorous acid is neutralized so quickly that it doesn’t kill all the bacteria,” he said. “It just helps reduce bacterial populations to more normal levels. You don’t want a population of pseudomonads moving in on the lid because all of the staphylococci have been killed off.”

    The next step in the clinical program is to examine changes in bacterial populations and diversity after a normal course of treatment.

    Editorial: Are we ophthalmologists in the eye of the storm?

    The product is used twice daily for 10 to 14 days for acute treatment. However, most patients continue use indefinitely.

    Preliminary indications suggest changes similar to the 20-minute sample, Dr. Stroman said, but a controlled trial is needed.

    “It is easy to look at the in vitro data and say hypochlorous acid removes everything, but the reality is that it does not sterilize the skin,” Dr. Epstein said. “You can’t practically sterilize the skin in the clinical setting and you don’t want to. But you can reduce the bacterial load on the lid surface and that makes a phenomenal difference to your patients.”

     

    More: Sustained-release dexamethasone depot effective in lowering fluorescein staining

     

    Arthur B. Epstein, OD

    E: [email protected]

    This article was adapted from a presentation by lead author David Stroman, PhD, senior vice president of ophthalmology development for NovaBay Pharmaceuticals, at the 2016 meeting of the Association for Research in Vision and Ophthalmology.

    New Call-to-action

     

    New Call-to-action

    0 Comments

    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available

    Poll

    View Results