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    Improving the prognosis of uveal melanoma

    Chicago—About one-half of people diagnosed with uveal melanoma ultimately develop metastatic disease. A look at survival rates for patients with uveal melanoma indicate that not much has changed in the past several decades or even for the past 100-plus years.

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    Nevertheless, there is good reason to be optimistic about the future considering the recent developments and ongoing research in this field, said Mary Beth Aronow, MD, at Ocular Oncology and Pathology 2016.

    “It would be easy to have a gloomy outlook on where we stand with uveal melanoma and to feel we have not made progress,” said Dr. Aronow, assistant professor of ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore. “However, I think we have made significant advances and we are working in exciting times.”

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    Dr. Aronow discussed how developments in imaging, prognostication, clinical trials, and therapies combined with a collaborative effort are changing the landscape of ophthalmic oncology.

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    Progress in the area of imaging has come with the availability of ultra-wide-field fundus imaging that allows for documentation of the appearance of the entire tumor and lesional response to treatment. Ultra-wide-field imaging systems are also available now for fluorescein angiography and for indocyanmice green angiography, which has been particularly useful for assessing choroidal tumors.

    There have also been advances optical coherence tomography (OCT) technology, and the introduction of enhanced depth imaging systems in particular has been very helpful for characterizing the ultrastructural features of smaller tumors and indeterminate lesions, Dr. Aronow said.

    Impact of OCT angiography

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