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    Low-dose atropine for myopia in children: two years of experience

    Nightly treatment with atropine drops can significantly slow progression

     

    ATOM1 and ATOM2

    The ATOM1 study showed that 1% atropine administered nightly over a 2-year period slowed myopic progression by 77%.1ATOM2 went on to demonstrate that the effect was dose-dependent and that 0.01% was sufficient to significantly suppress myopia progression.2

    A ‘rebound effect’ was evident in both studies: that is, myopia increased when the atropine treatment was stopped, to a greater extent in children who had received higher doses. The least rebound effect was seen with 0.1% atropine; patients receiving this dose had the least overall progression of myopia after 5 years (3 years after the end of treatment).3

    Two years of 0.01% atropine treatment provided, after 5 years, a 50% reduction of myopia compared with the predicted value.4

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