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    How new eye drop is stabilizing and relieving dry eye

    Water-free treatment has 'very positive' outlook for patients


    Twenty-five patients completed the study according to the study protocol. Investigators found that BCVA and IOP were unaffected by F6H8. Interestingly, tear osmolarity decreased significantly only in the right eyes.

    The Schirmer I test results and TFBUT both increased significantly during the study, reflecting the improved tear secretion and tear film stability. The OSDI decreased significantly from 55 to 34, which indicated decreased severity of the subjective symptoms. Corneal staining also decreased significantly after five to seven weeks. Finally, the meibum quality improved in seven patients, according to Dr. Steven.

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    Most questionnaire responses from patients were “very positive” regarding use of the drug and symptom relief.

    F6H8 appeared to be very safe. Five adverse effects were reported during the study, none of which were considered serious. Three patients reported mild to moderate hypersensitivity to F6H8. One patient reported recurrent rheumatoid arthritis, which was probably not related to the drug, and discontinued use of F6H8.

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    Investigators reported their findings in the Journal of Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther. 2015;31:498-503).

    “This prospective observational study shows significant beneficial effects in patients suffering from evaporative dry eye disease, using F6H8 in all the relevant parameters tested,” the investigators concluded. “The decrease of the OSDI by a mean of 21 points was particularly remarkable and clearly exceeds minimal, clinical important differences for mild or moderate and severe disease. Overall, F6H8 seems to be safe and effective in treating mild to moderate hyperevaporative dry eye disease.”

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