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    Ocular perfusion pressure, cerebrospinal fluid pressure: New players in glaucoma


    Numerous studies confirm

    Numerous large studies of glaucoma have looked at thousands of patients worldwide, notably the Baltimore Eye Survey, the Barbados Eye Survey, and the Los Angeles Latino Eye Survey, all population-based studies. The results of these studies pointed to the impact of low OPP in the development of glaucoma.

    The Baltimore Eye Survey and the Los Angeles Latino Eye Survey found that lower diastolic perfusion pressure was associated significantly with a higher risk of glaucoma.

    At the other end of the spectrum very high blood pressure (BP) might increase the risk of glaucoma.

    This effect of low pressure also was seen in a study of a European population, i.e., the lower the diastolic BP, the greater the prevalence of glaucoma was, according to Dr. Liebmann.

    The Barbados Eye Survey showed that in patients of African ancestry over 40 years of age, 2.2% of patients had an incidence of open-angle glaucoma after 4 years. Dr. Liebmann explained that this is “extraordinarily high” and found that the lower the OPP, the greater the risk for glaucoma.

    “Lower perfusion pressure was a tremendous risk factor in the African-descent population in Barbados and increases the risk of disease onset,” he added.


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