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    Precision medicine coming to glaucoma via specific pathways

    Genetic study a step toward more effective screening, diagnosis, treatment of POAG

    Emerging data from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study recognizes glaucoma as a set of multiple diseases, said Joan M. O’Brien, MD.

    POAAGG, a 5-year study funded by the National Eye Institute, is the largest genetic study of African Americans with primary open-angle glaucoma (POAG) to date. POAAGG researchers are beginning to identify distinct genetic variants associated with clinical phenotypes of POAG.

    Characterizing the genetic elements linked to different types of glaucoma could help clinicians develop more precise and effective treatments.

    “We are working to explore and exploit the genetic differences that underlie the phenotypic variation in glaucoma,” said Dr. O’Brien, chair of the University of Pennsylvania’s Department of Ophthalmology, Scheie Eye Institute, Philadelphia, and primary investigator of POAAGG.


    Fred Gebhart
    The author is a correspondent for Urology Times, a sister publication.

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