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    Punctal plug drug delivery attractive method for managing glaucoma


    The Ocular Therapeutix technology is a dissolving intracanalicular depot. The plug is invisible to the patient, but is fluorescent at the slit lamp.

    “Because this plug is intracanaliuclar, it is a little more difficult to remove than the other device, and the removal may require irrigation or physical manipulation” Dr. Moster said.

    A clinical trial was conducted evaluating a travoprost punctum plug composed of the prostaglandin analogue encapsulated in polyactide microparticles in a resorbable hydrogel rod.

    Upon exposure to the tear film, the rod swells within the canaliculus, causing hydrolysis of the microparticles and sustained release of the drug load into the tear film.

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