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    Researchers, scientists flock to East Coast for ARVO 2017

    ‘Global Connections’ theme emphasizes scientific teamwork for advancing vision science

     

    Minisymposia

    Genetics and modeling of lens and anterior segment

    Sunday, 3:15 to 5 p.m.

    This minisymposium will identify genetic lesions underlying lens and anterior segment anomalies in human patients and modeling these in a variety of in vitro and in vivo systems to identify the cellular and molecular mechanisms underlying ocular pathologies.
     

    Common pathogenic role of inflammation in retinal diseases

    Monday, 8:30 to 10:15 a.m.

    The minisymposium will focus on immunological properties of the inflammatory response associated to major retinal pathologies, encompassing cellular aspects of the local microglial response and stimulating the notion of targeting inflammation to ameliorate the disease.

     

    Optic nerve regeneration: Barriers past and future

    Monday, 8:30 to 10:15 a.m.

    Vision loss due to traumatic, ischemic, and degenerative optic nerve conditions such as glaucoma is generally unrecoverable primarily because in mammals retinal ganglion cells, like other neurons throughout the central nervous system, fail to regenerate their axons beyond the site of injury to re-innervate their targets in the brain. Recent discoveries have uncovered endogenous mechanisms within retinal ganglion cells (RGC) that boost axon growth capacity, as well as RGC-intrinsic and RGC-extrinsic barriers to regeneration. When some of these factors are experimentally manipulated in animal models, they promote potent regenerative axon regrowth that extends beyond the site of injury through the optic nerve and, in some instances, reach the appropriate central targets culminating in the formation of appropriate synapses and functional recovery. This minisymposium will describe recent discoveries in this field, and will outline the critical barriers remaining before optic nerve regeneration can be used clinically.
     

    Applications of adaptive optics for retinal imaging and visual function testing

    Monday, 11 a.m. to 12:45 p.m.

    New applications of adaptive optics are emerging for in vivo probing of retinal structure and function. The concept of adaptive optics will be explained for a wide variety of techniques, followed by several applications made possible by this technology.
     

    Barrier function of ocular surface

    Monday, 11 a.m.-12:45 p.m.

    This minisymposium focuses on the primary function of the ocular surface, that is, the barrier function. The session includes morphological, biological, and immunological characteristics of the barrier function. The speakers will talk about how barrier functions are regulated and how their impairments are related to the development of major ocular surface diseases such as dry eye, infection, and allergy.
     

    Optical coherence tomography in pediatric neuro-ophthalmology

    Monday, 11 a.m. to 12:45 p.m.

    Optical coherence tomography (OCT) has revolutionized the diagnosis and treatment of adults with retinal and optic nerve diseases, but until recently has not been readily available for use in children. Hand-held OCT now provides the possibility of imaging the retina and optic nerve head in infants and children from birth onwards. This minisymposium seeks to provide an overview of what we can currently achieve using hand-held OCT for the diagnosis and monitoring of pediatric neuro-ophthalmology cases.
     

    Novel therapies and imaging techniques for retinal disorders

    Tuesday, 8:30 to 10:15 a.m.

    Numerous scientific breakthroughs have allowed translational research of stem cell and gene therapy for inherited retinal disorders such as retinitis pigmentosa and atrophic AMD to develop at a rapid pace. Similarly, adaptation of OCT technology to integrated microscopic heads-up displays and non-invasive angiography are changing the way clinicians diagnose and treat patients. This minisymposium will highlight current retinal research and clinical application in therapeutics (stem cell and gene therapy for inherited retinal disorders) and  diagnostics (OCT-angiography and intra-operative OCT).

    Age-related changes in optics of the eye and vision

    Tuesday, 11 a.m. to 12:45 p.m.

    A better understanding of age-related changes in ocular components provides both scientifically and clinically important insights into mechanisms underlying the normal aging process of the eye and their association with age-related blinding eye diseases, leading to increasing the potential to detect and treat the diseases as early as possible.
     

    Corneal dystrophies: Where do we stand?

    Tuesday, 11 a.m. to 12:45 p.m.

    This minisymposium will include discussion of three major blinding diseases--corneal dystrophy, keratoconus, and Fuch’s dystrophy. Session presentations will span novel cell biological mechanistic studies, clinical treatments and outcomes, and challenges to commercialization.

     

    ER stress and the unfolded protein response in ocular health and disease

    Tuesday, 11 a.m. to 12:45 p.m.

    Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are involved in the development of many ocular progressive disorders including retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, glaucoma, and cataract. The minisymposium highlights roles of ER stress and UPR in progression of ocular diseases, presents different therapeutic strategies to treat ocular diseases, and emphasizes the need to promote a field from lab bench to clinical trials.

    Beyond the retina: Central visual circuits

    Tuesday, 3:45 to 5:30 p.m.

    The topics in this minisymposium will address the circuitry and plasticity of visual processing of various visual brain regions. Speakers will discuss dLGN, sub-cortical and cortical circuits, and the integration of signal diversity established by RGC output. Speakers will emphasize  use of optogenetics and new transgenic tools that are rapidly advancing our understanding of the how the visual percept is formed.

    (Continued) Wednesday schedule


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