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    SD-OCT may help diagnose primary vitreoretinal lymphoma



    The researchers recommend prompt referral of patients with such findings to specialised uveitis services, and early consideration of oncology review. Early diagnosis of ocular lesions prior to the development of central nervous system disease can prolong life, they explained.

    In addition to SD-OCT, fluorescein and indocyanine green angiography could also contribute to the diagnosis of PVRL, they suggested, adding that such tests have a positive predictive value of 89% and a negative predictive value of 85%.

    On fluorescein angiography, punctuate hyperfluorescent window defects, round hypofluorescent lesions, masking and granularity can suggest PVRL. On indocyanine green angiography, small hypofluerescent lesions in the early phase become less apparent in the late frames.

    Infiltration due to PVRL often improves with steroid therapy, leading to diagnostic confusion, they noted, so steroid therapy should halt for 2 weeks before a biopsy.

    The researchers speculated that the OCT features they identified represent infiltrating lymphoma cells at various levels in the retina. Larger studies are needed to confirm whether the features identified are truly specific to PVRL, they concluded.

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