/ /

  • linkedin
  • Increase Font
  • Sharebar

    Selective two-photon collagen crosslinking: Why more is better

    Technique mechanically strengthens corneal tissue in situ without damage to surrounding untreated tissue

     

    Compared with conventional procedures for evaluating 2P-CXL-induced stiffening, Brillouin microscopy does not require perturbation of the surrounding non-crosslinked regions, they noted.

    The investigators commented, “Our results demonstrate the ability to alter the microstructure and mechanical modulus locally in the cornea by 2P-CXL with microscopic resolution and illustrate the unique advantage of Brillouin microscopy in evaluating 2P-CXL-induced changes nondestructively.”

    They also pointed out other uses for 2P-CXL in ophthalmology in addition to treating thin ectatic corneas (<400 μm), such as corneal flap bonding post-LASIK, and the selective modulation of corneal curvature for refractive error correction.

    “Since 2P-CXL has such high spatial selectivity in three-dimensions, and the fact that it is a non-surgical and non-invasive technique,” Kwok said, “it could have unique advantages for correcting refractive errors in patients.”

    More: Technique targets source of rainbow glare symptoms

    Recent: What literature review says about modern LASIK

     

    Seok Hyun Yun, PhD

    E: syun@hms.harvard.edu

    Dr. Yun and Mr. Kwok have a patent pending for this technology. The institutions involved in this research were Harvard-MIT Division of Health Sciences and Technology and Wellman Center for Photomedicine at Massachusetts General Hospital, both in Boston; and the Departments of Biomedical Engineering at Johns Hopkins University, Sungkyunkwan University, and University of Maryland, in Baltimore, Suwon, South Korea, and College Park, MD, respectively.

    New Call-to-action

    0 Comments

    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available

    Poll

    View Results