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    Selective two-photon collagen crosslinking: Why more is better

    Technique mechanically strengthens corneal tissue in situ without damage to surrounding untreated tissue


    Compared with conventional procedures for evaluating 2P-CXL-induced stiffening, Brillouin microscopy does not require perturbation of the surrounding non-crosslinked regions, they noted.

    The investigators commented, “Our results demonstrate the ability to alter the microstructure and mechanical modulus locally in the cornea by 2P-CXL with microscopic resolution and illustrate the unique advantage of Brillouin microscopy in evaluating 2P-CXL-induced changes nondestructively.”

    They also pointed out other uses for 2P-CXL in ophthalmology in addition to treating thin ectatic corneas (<400 μm), such as corneal flap bonding post-LASIK, and the selective modulation of corneal curvature for refractive error correction.

    “Since 2P-CXL has such high spatial selectivity in three-dimensions, and the fact that it is a non-surgical and non-invasive technique,” Kwok said, “it could have unique advantages for correcting refractive errors in patients.”

    More: Technique targets source of rainbow glare symptoms

    Recent: What literature review says about modern LASIK


    Seok Hyun Yun, PhD

    E: [email protected]

    Dr. Yun and Mr. Kwok have a patent pending for this technology. The institutions involved in this research were Harvard-MIT Division of Health Sciences and Technology and Wellman Center for Photomedicine at Massachusetts General Hospital, both in Boston; and the Departments of Biomedical Engineering at Johns Hopkins University, Sungkyunkwan University, and University of Maryland, in Baltimore, Suwon, South Korea, and College Park, MD, respectively.

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