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    Shire's FDA-approved drug ends dry eye treatment drought

     

    How the drug works

    The inflammation associated with dry eye is thought to be primarily mediated by T-cells and associated cytokines. One effect of this process may be increased expression of intracellular adhesion molecule-1 (ICAM-1); ICAM 1 may be overexpressed in corneal and conjunctival tissues in dry eye disease.

    Editorial: Unpopular science

    Lifitegrast is a small-molecule integrin antagonist that binds to the integrin lymphocyte function-associated antigen-1 (LFA-1), a cell surface protein found on leukocytes, and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1). LFA-1/ICAM-1 interaction can contribute to the formation of an immunological synapse resulting in T-cell activation and migration to target tissues.

    Blog: Keys to finding balance in a successful practice

    In vitro studies demonstrated that lifitegrast may inhibit T-cell adhesion to ICAM-1 in a human T-cell line and may inhibit secretion of inflammatory mediators (cytokines) in human peripheral blood mononuclear cells. The exact mechanism of action of lifitegrast in dry eye disease is not known.

    The drug has been approved for patients 18 years of age and older.

    More: FDA approves one-of-a-kind IOL

    Jolie Higazi
    Jolie is the Content Specialist for Ophthalmology Times. She can be reached at [email protected]

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    • [email protected]
      It sounds like a great news for potential dry eye patients. Its great that contact lenses are now better than what they used to be . You can shop them at gkb opticals
    • Anonymous
      It sounds like a great news for potential dry eye patients. Its great that contact lenses are now better than what they used to be . You can shop them at gkb opticals

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