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    Sustained-release topical rings promising for glaucoma

    Study aims to compare effectiveness, safety of rings versus eye drops


    The bimatoprost group had a higher percentage of ocular treatment-emergent adverse events than the timolol group. The difference in ocular adverse events was 45.3% versus 34.8%. The most common adverse event was eye discharge, followed by conjunctival hyperemia and punctuate keratitis. Ten patients withdrew from the study due to adverse events, nine from the bimatoprost group and one from the timolol group. All of the adverse events resolved.

    Researchers are also working on another alternative treatment for glaucoma – injectable, sustained release drugs. Still, the topical rings are less likely to cause severe adverse events, Dr. Brandt said.

    “There is a very good safety record of injections being done for patients with macular degeneration,” he said. “But the vast majority of patients with macular degeneration receiving regular injections are likely to lose vision quickly without the injections, so the small risk of injections is acceptable. In contrast, in someone with early glaucoma, the risk of going blind during their lifetime is relatively small, so any intervention in these patients must be very safe. The bimatoprost ring has demonstrated a safety and efficacy profile that fits the needs of an early stage glaucoma patient.”

    Earlier this year, Allergan announced it will acquire the company that makes the bimatoprost ring, ForSight Vision5. “The acquisition of this ring technology demonstrates our commitment to advancing products that can profoundly change the way patients receive treatment – through innovation that helps address non-compliance, increases adherence and improves tolerability,” Brent Sunders, chief executive officer, Allergan, said in a statement.



    1          Newman-Casey, P.A., et al., Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up. Ophthalmology, 2015. 122(10): p. 2010-21.

    2.         Brandt, J.D., et al., Comparison of once- or twice-daily bimatoprost with twice-daily timolol in patients with elevated IOP - A 3-month clinical trial. Ophthalmology, 2001. 108(6): p. 1023-1031.


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