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    Targeting TGF-beta in different ocular diseases

    ISTH0036 down-regulates drug signaling in preclinical GFS, CNV models


    Antagonism of TGF-β2 may be a “transforming” modality in the management of glaucoma after trabeculectomy, by preventing increases in IOP after trabeculectomy, exerting a neuroprotective effect on the optic nerve, and preventing scarring via an antifibrotic effect, he explained.


    Keep up the with latest surgery news here

    “We clearly demonstrated in both GFS and CNV murine models that ISTH0036, when infrequently injected intraocularly, induces biologic responses consistent with expected molecular mechanism and long-lasting distribution in relevant eye tissues,” Dr. Janicot said.

    The FDA and European Medicines Agency both have granted orphan drug designation for ISTH0036 for preventing scarring after GFS.

    Patients are currently being recruited for a phase I open-label, dose-escalation study to investigate the safety of ISTH0036, in subjects with primary open-angle glaucoma undergoing trabeculectomy. The first patient was treated in April 2015.



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