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    Unraveling the complex role of perfusion pressure in glaucoma progression

    Pressure rate under closer scrutiny since investigation began into the disease’s causes



    The data, Dr. Harris noted, corresponds to some of the data from the previously mentioned population-based studies, and offers an explanation of those data.

     “Patients with low blood pressure that lack the ability to autoregulate have lower blood flow levels at any given level of IOP, and, we believe, may have early venous collapse,” he said. “We concluded that high IOP values are likely to be the dominant factor in ocular perfusion pressure causing inadequate or dysfunctional autoregulation.”

    He summarized that previous studies are consistent on the finding that low perfusion pressure is a risk factor for glaucoma.

    Top-paying states for ophthalmic techs

    In theory, ocular perfusion pressure can be incorporated into glaucoma management as a risk factor or a treatment target. However, based on our current knowledge, we must first improve our understanding of the role of perfusion pressure in glaucoma. The complexity of perfusion pressure in and of itself and its interaction with potential risk factors for glaucoma still need to be determined.

    Synergy between math models and clinical studies can help weigh the contributions of different factors and mechanisms that influence autoregulation of blood flow in the eye and in the clinical interpretation of data. He said he believes that this understanding may lead in the future to patient-specific evaluations elucidating the complex relationship between IOP, blood pressure, cerebrospinal fluid pressure, and optic nerve blood flow.



    Alon Harris, MS, PhD

    E: [email protected]

    Dr. Harris has no financial interest in any aspect of this report.

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