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    What physicians need to know about bacterial resistance

    La Jolla, CA—In vitro antibiotic resistance—defined as the ability for bacteria to exist and multiply despite a normally achievable serum level of drug that had been previously determined to successfully treat a clinical infection—is an increasing problem worldwide.

    Resistance is determined based on serum standards, however. Taking into account the high concentrations of antibiotic achievable in ocular tissues, antibiotic resistance does not necessarily correspond with poor clinical efficacy when treating infections in ophthalmology, said Francis S. Mah, MD.

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    Regional data on antibiotic minimum inhibitory concentration (MIC) and resistance rates are factors ophthalmologists should consider when choosing antibiotics for prophylaxis and as empiric treatment, said Dr. Mah, director, cornea and external diseases and co-director, refractive surgery, Scripps Clinic Torrey Pines, La Jolla, CA.



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